This landscape identifies 1,221 published records matching the combination of analytical methods (such as capillary isoelectric focusing and size exclusion chromatography) and monitoring purposes (such as deamidation monitoring and aggregate quantification) that define the field. The dataset spans filings from 2015 through the mid-2026 data cut-off. Because publication lags filing by roughly 18 months, the true count of recent filings is understated for the last one to two years shown in any trend chart.

The ranking covers 100 assignees, with the leading company holding 123 records, more than double the fifth-place holder at 42 and the tenth-place holder at 28. Together the top five assignees account for 340 records, or 27.8% of the full 1,221-record dataset. That still leaves nearly three-quarters of filings spread across a long tail of smaller and single-filing entrants, so the field is concentrated at the top but far from closed.

The dominant IPC subclass is C07K (peptides and proteins), present in 49.9% of the 1,221 records, followed by A61K (medicinal preparations) at 41.1% and G01N (material analysis and testing) at 36.5%. Smaller but meaningful shares appear in C12N, C12Q, B01D and C12P, reflecting claims that reach into cell-line engineering, enzymatic assays, filtration hardware and fermentation processes. A single record commonly carries several of these classes at once, which is why the shares add up to more than 100%.