NADPH regeneration patents: mapping cofactor recycling claims for biocatalysis

This landscape identifies 59 published records between 2015 and 2026 that combine NADPH regeneration or recycling language with biocatalysis, enzymatic conversion or microbial fermentation, filtered to C12N and C12P classification. The true worldwide total is larger once therapy- and diagnostic-framed filings and broader classification codes are included, but this scope isolates the engineering-focused subset. Because publication lags filing by roughly 18 months, the most recent one to two years will keep rising as more records publish.

The ranking covers 43 assignees, with the leader holding 11 of the 59 records and the top five combined accounting for 55.9% of the field. That leaves a substantial long tail of academic institutions, industrial biotech firms and individually named inventors each holding a handful of records, so no single organisation controls the space outright. Anyone assessing competitive risk should look at the top ten as a group, which together hold 83.1% of records, rather than fixating on the single leader.

Almost every record in scope, 96.6% of the 59, falls under both C12N (microorganisms and genetic engineering) and C12P (fermentation and enzymatic synthesis), meaning claims are overwhelmingly framed around engineered strains and enzymatic conversion processes. Secondary classes like C10G hydrocarbon oils and the C12R/C12S microorganism index each cover about a quarter of records, reflecting industrial fermentation applications. Thinner branches such as C07H sugars and nucleic acids, at 6.8%, indicate less-claimed adjacent chemistry.