Crystal Habit Patents: Who Leads, Where the Gaps Are 2026
- 32.6% concentration. The top five assignees hold 1,206 of the 3,697 records in scope, but the ranked field runs 100 companies deep with a long single-filing tail.
- Filing peaked in 2021. 280 records that year, falling to 116 by 2024 (-59%) — a real slowdown, not a data artefact, since 2024 is the last complete year before publication lag distorts the count.
- A61K and C07D dominate claim space. 54.4% and 44.3% of records respectively, meaning most filing pressure sits on formulation and heterocyclic composition, not on physical-process classes like B01J (3.2%) or C11D (2.8%).
Filing growth compares 2021 (280 records) with 2024 (116) — a three-year span. 2024 is the most recent year we treat as complete: publication lags filing by roughly 18 months, so 2025 onwards are still filling in and any growth rate that ends there would understate the field. Top-5 share is the combined record count of the five largest assignees divided by all 3,697 records in scope (CR5), not by the ranked leaders only.
What this landscape covers
This landscape tracks patent activity at the intersection of crystal habit control and the downstream manufacturing consequences that follow from it — filtration rate, bulk density, powder flowability, milling requirement and tabletting behaviour. These are the properties that decide whether a promising crystalline form survives contact with a real manufacturing line, and filers treat them as a distinct claim territory from polymorph discovery itself.
The scope spans 3,697 published records filed between 2015 and mid-2026, drawn from a search string that pairs morphology-control language with the specific processability failure modes — needle crystals, poor filtration, low bulk density — that drive reformulation work in pharmaceutical manufacturing.
Filing trends and technology composition
Two views of the same 3,697-record set: how filing volume has moved year over year, and which technology classes carry the claim density.
A 2021 peak followed by a real pullback
Filings rose from 153 in 2017 to a peak of 280 in 2021, then declined to 116 by 2024 — a -59% move over that three-year span. Because publication lags filing by roughly 18 months, 2025 and 2026 figures are still filling in and should not be read as a continuation of the decline.
Formulation and heterocyclic chemistry carry the density
A61K (medicinal preparations) and C07D (heterocyclic compounds) each appear on well over 40% of records, with A61P (therapeutic activity) close behind at 39.8%. Physical-process classes such as B01J and C11D are present but comparatively thin, at 3.2% and 2.8% of records respectively — a signal about where claim space is crowded versus where it is not.
Shares are the percentage of the 3,697 records in scope. A patent can carry several IPC classes, so the shares add up to more than 100%.
Go deeper on Crystal Habit and Downstream Processability with Eureka
This page is one run against one query. Ask Eureka your own question about crystal habit and downstream processability and every answer comes back with the patent numbers behind it.
Try EurekaRepresentative filing and most-cited prior art
Forming spherical crystal habit (US8962888B2)
Methods for forming spherical crystal habit are shown. A needle-shaped crystal habit, a solvent, and a surfactant are combined and dissolved forming a first solution. The first solution and an anti-solvent are combined forming a second solution. The second solution is cooled. Spherical crystal habit is formed.Filed by Physical Sciences, Inc., published 2015-02-24.


| # | Publication no. | Patent title | Citations |
|---|---|---|---|
| 1 | US4902600A | Light-sensitive material comprising light-sensitive layer provided on support wherein the light-sensitive lay… | 163 |
| 2 | US3855147A | Synthetic smectite compositions, their preparation, and their use as thickeners in aqueous systems | 145 |
| 3 | WO2002038127A2 | Particle formation methods and their products | 134 |
| 4 | WO2012121764A1 | Novel salts and polymorphic forms of afatinib | 114 |
| 5 | US6406718B1 | Orthorhombic crystalline form of fluticasone propionate and pharmaceutical compositions thereof | 98 |
| 6 | WO1999004774A2 | Nucleotide analog compositions | 98 |
| 7 | WO1998017676A1 | A novel polymorphic crystalline form of fluticasone propionate, a method for its production and pharmaceutica… | 96 |
| 8 | US4476248A | Crystallization of ibuprofen | 95 |
| 9 | US4357184A | Explosive compositions based on time-stable colloidal dispersions | 95 |
| 10 | US6451340B1 | Nucleotide analog compositions | 93 |
Citation counts reflect influence within this searched corpus and skew toward older filings; they are not a measure of current commercial importance.
Each row carries its publication number; clicking a row searches Eureka by that number.
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Three patterns stand out once volume, concentration and class composition are read together.
The top of the field is thick, not dominant
The five leading assignees account for 32.6% of all 3,697 records, and the top ten reach 41.8%. That leaves well over half the field to the remaining 90 ranked companies and an unranked tail — concentrated enough to matter for freedom-to-operate checks, but not so concentrated that new entrants are locked out of the whole space.
The peak has passed, the leaders have gone quiet
Filing volume fell from 280 in 2021 to 116 in 2024. Several of the most active named assignees show flat or sharply negative year-on-year momentum in the most recent complete year, suggesting the wave of activity that built the current leaderboard has already crested rather than being mid-build.
Claims cluster on formulation, not on process equipment
A61K and C07D between them touch the large majority of records, while process-oriented classes like B01J (chemical/physical processes) sit under 5%. Filers are claiming the pharmaceutical composition and the crystal form far more than they are claiming the milling, filtration or granulation equipment path that gets a molecule there.
Eureka can read the same corpus for gaps instead of for coverage: under-claimed branches adjacent to crystal habit and downstream processability, with the prior art for and against each one.
Who is filing, and where the gaps sit
The leaderboard is anchored by a small group of pharmaceutical and specialty-chemical filers, several of them linked by shared co-assignee filings, with a long tail of single- or few-filing entrants behind them.
A single filer well ahead of the field
The leading assignee holds 508 records, more than four times fifth place at 104 — a gap wide enough to suggest a sustained, deliberate filing programme rather than opportunistic coverage.
Corporate family filing shows up as co-assignee pairs
The strongest co-assignee pair shares 81 records, consistent with related corporate entities filing jointly across jurisdictions rather than two independent companies collaborating. Ten such pairs exist in total, mostly linking entities that appear to be regional arms of the same groups.
Plenty of room below the leaders
With the top ten holding 41.8% of records, the remaining ranked companies and the unranked filers behind them hold the majority of the field. This is not a two-player market: it rewards a freedom-to-operate search that goes past the obvious names.
| Assignee | Recent year | YoY |
|---|---|---|
| Assia Chemical Industries | 1 | -95% |
| Novartis AG | 1 | 0% |
| Teva Pharmaceuticals International GmbH | 0 | -100% |
| TEVA PHARMACEUTICALS USA INC | 0 | — |
| Signal Pharmaceuticals LLC | 0 | — |
| Ratiopharm GmbH | 0 | — |
| Actuate Therapeutics, Inc. | 0 | — |
| Pliva-Hrvatska d.o.o. | 0 | — |
Where to take this next
The dataset points to specific next steps depending on whether the goal is defensive clearance or offensive filing.
Run a freedom-to-operate check past the leaderboard
With 90-plus companies outside the top ten holding the majority of records, a clearance search limited to the obvious leaders will miss real prior art.
Explore assignee data in EurekaWatch the process-equipment classes
B01J and C11D sit well under 5% of records despite covering the physical steps that determine flowability and filtration outcomes — a candidate area for new claims.
Map white space in EurekaTrack whether filing has genuinely cooled
The -59% move from 2021 to 2024 is real, but 2025-2026 data is still incomplete; confirm the trend holds once publication catches up before treating the field as settled.
Monitor filing trends in EurekaCommon questions about this landscape
Crystal habit patents claim the external shape and morphology of a crystalline particle — needle, plate, spherical and so on — and the process conditions used to control that shape, whereas polymorph patents claim a distinct internal crystal lattice arrangement of the same molecule. The two frequently overlap in practice because changing habit often accompanies a polymorphic transition, but this landscape is scoped specifically to habit and its downstream manufacturing consequences: filtration rate, bulk density, flowability, milling requirement and tabletting behaviour. A claim that only recites a melting point or XRPD pattern without tying it to a processability outcome sits outside this scope.
Filing volume rose to a peak of 280 records in 2021 and had fallen to 116 by 2024, a -59% change over that span. This kind of pullback after a peak year is common once early movers have covered the most obvious combinations of solvent, anti-solvent and surfactant conditions, leaving fewer novel process claims for later filers. It is worth noting that 2025 and 2026 figures in any such dataset are understated because publication typically lags the actual filing date by around 18 months, so the most recent one to two years should not be read as confirming a continued decline.
The field is led by a small group of pharmaceutical and specialty-chemical companies, with the top assignee holding 508 records against 104 at fifth place and 55 at tenth — a meaningful gap that points to a sustained filing programme rather than incidental coverage. Several of the leading names are linked through co-assignee filings, most likely reflecting related corporate entities filing jointly across jurisdictions. Even so, the top ten account for only 41.8% of the 3,697 records in scope, so a large share of the field sits with companies outside the most visible names.
The technology composition data shows a heavy skew toward formulation and therapeutic-activity classes (A61K at 54.4%, C07D at 44.3%, A61P at 39.8% of records), while process-oriented classes such as B01J (chemical and physical processes) and C11D (detergents and cleaning compositions) sit under 5%. That gap suggests process-equipment claims — milling parameters tuned to specific needle habits, continuous filtration setups, or bulk-density-targeted anti-solvent addition sequences — are comparatively under-claimed relative to composition-of-matter claims on the crystal form itself.
Not necessarily. Citation counts inside a searched patent corpus accumulate over time, so older records have simply had more years to be cited and tend to dominate any most-cited list regardless of current relevance. A citation count is better read as a signal of historical influence on later filings in the same space than as an indicator that the underlying technology or claim is still central to today's commercial activity. Checking the filing date and current legal status alongside the citation count gives a more reliable read on relevance.
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Disclaimer. This page is generated from Patsnap Eureka data drawn from a limited snapshot of global patent and scientific-literature records, and is provided for general information and reference only.
Patent data carries inherent limitations: recent filings (typically the most recent 18–24 months) are under-counted due to standard publication lag; counts may be reported at either a patent-family or a patent-record basis and are not always directly comparable; classification, applicant-name, and citation data may contain errors, duplicates, or omissions; and the underlying search query defines and constrains the scope shown. As a result, the analysis may be incomplete or inaccurate and may not reflect the full technology landscape.
Nothing on this page constitutes an exhaustive prior-art, novelty, freedom-to-operate, or validity search, nor does it constitute legal, financial, investment, or professional advice, and it should not be relied upon as such. Any patent, commercial, or strategic decision should be verified independently and reviewed with qualified patent, legal, and domain professionals. Patsnap makes no warranties, express or implied, as to the accuracy, completeness, or fitness for any particular purpose of the information presented.
Machine translation. Assignee and organisation names originally recorded in Chinese, Japanese or Korean have been rendered into English by an AI translation step so that the tables stay readable. These renderings are best-effort and may not match a company’s registered English name; the original name is what the underlying patent record carries, and it is what any Eureka query launched from this page uses.