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Crystal Habit Patents: Who Leads, Where the Gaps Are 2026

Crystal Habit Patents: Who Leads, Where the Gaps Are 2026
https://www.patsnap.com/resources/blog/rd-blog/crystal-habit-and-downstream-processability-patent-landscape/ · Patsnap · data cut-off 2026-07-31 · downloaded from the live page
Patent Landscape · Pharmaceutical Manufacturing
Crystal Habit and Downstream Processability Patents
  • 32.6% concentration. The top five assignees hold 1,206 of the 3,697 records in scope, but the ranked field runs 100 companies deep with a long single-filing tail.
  • Filing peaked in 2021. 280 records that year, falling to 116 by 2024 (-59%) — a real slowdown, not a data artefact, since 2024 is the last complete year before publication lag distorts the count.
  • A61K and C07D dominate claim space. 54.4% and 44.3% of records respectively, meaning most filing pressure sits on formulation and heterocyclic composition, not on physical-process classes like B01J (3.2%) or C11D (2.8%).
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3,697
Published Records
33%
Top-5 Share of All Records
-59%
Filing Growth 2021→2024
US
Leading Jurisdiction

Filing growth compares 2021 (280 records) with 2024 (116) — a three-year span. 2024 is the most recent year we treat as complete: publication lags filing by roughly 18 months, so 2025 onwards are still filling in and any growth rate that ends there would understate the field. Top-5 share is the combined record count of the five largest assignees divided by all 3,697 records in scope (CR5), not by the ranked leaders only.

Published byPatsnap Research··7 min readSourced from Patsnap Eureka
Overview

What this landscape covers

This landscape tracks patent activity at the intersection of crystal habit control and the downstream manufacturing consequences that follow from it — filtration rate, bulk density, powder flowability, milling requirement and tabletting behaviour. These are the properties that decide whether a promising crystalline form survives contact with a real manufacturing line, and filers treat them as a distinct claim territory from polymorph discovery itself.

The scope spans 3,697 published records filed between 2015 and mid-2026, drawn from a search string that pairs morphology-control language with the specific processability failure modes — needle crystals, poor filtration, low bulk density — that drive reformulation work in pharmaceutical manufacturing.

Filing activity, 2015-2026
  1. 1ASSIA CHEM IND508
  2. 2NOVARTIS AG211
  3. 3TEVA PHARMACEUTICALS INTERNATIONAL GMBH200
  4. 4TEVA PHARMACEUTICALS USA INC183
  5. 5SIGNAL PHARMACEUTICALS LLC104
  6. 6RATIOPHARM GMBH100
  7. 7ACTUATE THERAPEUTICS INC65
  8. 8FUJIFILM CORP60
  9. 9XENON PHARMACEUTICALS INC59
  10. 10TIANJIN HEMAY PHARM SCI TECH CO LTD55
Source: Patsnap Eureka. Assignee ranking and totals. Derived from a Patsnap search on Crystal Habit and Downstream Processability covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish.Run this in Eureka MCP
The Numbers

Filing trends and technology composition

Two views of the same 3,697-record set: how filing volume has moved year over year, and which technology classes carry the claim density.

A 2021 peak followed by a real pullback

Filings rose from 153 in 2017 to a peak of 280 in 2021, then declined to 116 by 2024 — a -59% move over that three-year span. Because publication lags filing by roughly 18 months, 2025 and 2026 figures are still filling in and should not be read as a continuation of the decline.

A 2021 peak followed by a real pullback07515022530015320172018201920202802021202220232024202592026Most recent year is partial — publication lag means later filings are not yet visible.

Formulation and heterocyclic chemistry carry the density

A61K (medicinal preparations) and C07D (heterocyclic compounds) each appear on well over 40% of records, with A61P (therapeutic activity) close behind at 39.8%. Physical-process classes such as B01J and C11D are present but comparatively thin, at 3.2% and 2.8% of records respectively — a signal about where claim space is crowded versus where it is not.

Formulation and heterocyclic chemistry carry the densityA61K · Medicinal preparations2,01254.4%C07D · Heterocyclic compounds1,63844.3%A61P · Therapeutic activity of compou…1,47239.8%C07C · Acyclic & carbocyclic compounds38910.5%C06B · Explosives & propellants1724.7%C01B · Non-metallic elements & inorga…1644.4%B01J · Chemical/physical processes & …1193.2%C11D · Detergents & cleaning composit…1032.8%Other1,51340.9%

Shares are the percentage of the 3,697 records in scope. A patent can carry several IPC classes, so the shares add up to more than 100%.

Source: Patsnap Eureka. Filing trend and technology composition. Derived from a Patsnap search on Crystal Habit and Downstream Processability covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish.

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This page is one run against one query. Ask Eureka your own question about crystal habit and downstream processability and every answer comes back with the patent numbers behind it.

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Key Patents

Representative filing and most-cited prior art

Representative Record
US8962888B22015-02-24

Forming spherical crystal habit (US8962888B2)

PHYSICAL SCIENCES, INC.

Methods for forming spherical crystal habit are shown. A needle-shaped crystal habit, a solvent, and a surfactant are combined and dissolved forming a first solution. The first solution and an anti-solvent are combined forming a second solution. The second solution is cooled. Spherical crystal habit is formed.Filed by Physical Sciences, Inc., published 2015-02-24.

US8962888B2 — patent drawing 1US8962888B2 — patent drawing 2
View full record
Most-cited records in this landscape
#Publication no.Patent titleCitations
1US4902600ALight-sensitive material comprising light-sensitive layer provided on support wherein the light-sensitive lay…163
2US3855147ASynthetic smectite compositions, their preparation, and their use as thickeners in aqueous systems145
3WO2002038127A2Particle formation methods and their products134
4WO2012121764A1Novel salts and polymorphic forms of afatinib114
5US6406718B1Orthorhombic crystalline form of fluticasone propionate and pharmaceutical compositions thereof98
6WO1999004774A2Nucleotide analog compositions98
7WO1998017676A1A novel polymorphic crystalline form of fluticasone propionate, a method for its production and pharmaceutica…96
8US4476248ACrystallization of ibuprofen95
9US4357184AExplosive compositions based on time-stable colloidal dispersions95
10US6451340B1Nucleotide analog compositions93

Citation counts reflect influence within this searched corpus and skew toward older filings; they are not a measure of current commercial importance.

Each row carries its publication number; clicking a row searches Eureka by that number.

Source: Patsnap Eureka. Citation counts and representative records. Derived from a Patsnap search on Crystal Habit and Downstream Processability covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish.Run this in Eureka MCP
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Insights

What the data means for a filing decision

Three patterns stand out once volume, concentration and class composition are read together.

Concentration
32.6%
of 3,697 records held by top 5

The top of the field is thick, not dominant

The five leading assignees account for 32.6% of all 3,697 records, and the top ten reach 41.8%. That leaves well over half the field to the remaining 90 ranked companies and an unranked tail — concentrated enough to matter for freedom-to-operate checks, but not so concentrated that new entrants are locked out of the whole space.

Based on the 100-company assignee ranking.
Momentum
-59%
2021 to 2024 filing change

The peak has passed, the leaders have gone quiet

Filing volume fell from 280 in 2021 to 116 in 2024. Several of the most active named assignees show flat or sharply negative year-on-year momentum in the most recent complete year, suggesting the wave of activity that built the current leaderboard has already crested rather than being mid-build.

2025-2026 figures are still incomplete due to publication lag.
Class skew
54.4% vs 3.2%
A61K share vs B01J share

Claims cluster on formulation, not on process equipment

A61K and C07D between them touch the large majority of records, while process-oriented classes like B01J (chemical/physical processes) sit under 5%. Filers are claiming the pharmaceutical composition and the crystal form far more than they are claiming the milling, filtration or granulation equipment path that gets a molecule there.

Class shares sum above 100% because records carry multiple IPC codes.
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Eureka can read the same corpus for gaps instead of for coverage: under-claimed branches adjacent to crystal habit and downstream processability, with the prior art for and against each one.

Find the white space →
Source: Patsnap Eureka. Co-assignee relationships and derived observations. Derived from a Patsnap search on Crystal Habit and Downstream Processability covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish.Run this in Eureka MCP
Players

Who is filing, and where the gaps sit

The leaderboard is anchored by a small group of pharmaceutical and specialty-chemical filers, several of them linked by shared co-assignee filings, with a long tail of single- or few-filing entrants behind them.

Leader
508
records

A single filer well ahead of the field

The leading assignee holds 508 records, more than four times fifth place at 104 — a gap wide enough to suggest a sustained, deliberate filing programme rather than opportunistic coverage.

Compare against 55 records at tenth place.
Co-filing
81
shared records, strongest pair

Corporate family filing shows up as co-assignee pairs

The strongest co-assignee pair shares 81 records, consistent with related corporate entities filing jointly across jurisdictions rather than two independent companies collaborating. Ten such pairs exist in total, mostly linking entities that appear to be regional arms of the same groups.

10 co-assignee pairs identified in scope.
Long tail
90+
companies outside the top 10

Plenty of room below the leaders

With the top ten holding 41.8% of records, the remaining ranked companies and the unranked filers behind them hold the majority of the field. This is not a two-player market: it rewards a freedom-to-operate search that goes past the obvious names.

Ranking covers 100 companies by record count.
🔍
Under-claimed sub-areas worth a closer look
Process-equipment and inorganic-adjacent classes carry far less claim density than the formulation core, which is where open filing room tends to sit.
milling-parameter claims for needle habitscontinuous filtration rate optimisationbulk-density-targeted anti-solvent crystallisationtabletting behaviour of low-flowability powdersinorganic co-crystal morphology control
Rank all filers by momentum →
Recent-year filing momentum by assignee
AssigneeRecent yearYoY
Assia Chemical Industries1-95%
Novartis AG10%
Teva Pharmaceuticals International GmbH0-100%
TEVA PHARMACEUTICALS USA INC0
Signal Pharmaceuticals LLC0
Ratiopharm GmbH0
Actuate Therapeutics, Inc.0
Pliva-Hrvatska d.o.o.0
Source: Patsnap Eureka. Assignee-level momentum. Derived from a Patsnap search on Crystal Habit and Downstream Processability covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish.Run this in Eureka MCP
What's Next

Where to take this next

The dataset points to specific next steps depending on whether the goal is defensive clearance or offensive filing.

Run a freedom-to-operate check past the leaderboard

With 90-plus companies outside the top ten holding the majority of records, a clearance search limited to the obvious leaders will miss real prior art.

Explore assignee data in Eureka

Watch the process-equipment classes

B01J and C11D sit well under 5% of records despite covering the physical steps that determine flowability and filtration outcomes — a candidate area for new claims.

Map white space in Eureka

Track whether filing has genuinely cooled

The -59% move from 2021 to 2024 is real, but 2025-2026 data is still incomplete; confirm the trend holds once publication catches up before treating the field as settled.

Monitor filing trends in Eureka
Source: Patsnap Eureka. Forward-looking reading of the same dataset. Derived from a Patsnap search on Crystal Habit and Downstream Processability covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish.Run this in Eureka MCP
FAQ

Common questions about this landscape

Answers are grounded in the same dataset. Derived from a Patsnap search on Crystal Habit and Downstream Processability covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish.Run this in Eureka MCP

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Go past this page: query the whole crystal habit and downstream processability corpus yourself, in your own scope.
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Disclaimer. This page is generated from Patsnap Eureka data drawn from a limited snapshot of global patent and scientific-literature records, and is provided for general information and reference only.

Patent data carries inherent limitations: recent filings (typically the most recent 18–24 months) are under-counted due to standard publication lag; counts may be reported at either a patent-family or a patent-record basis and are not always directly comparable; classification, applicant-name, and citation data may contain errors, duplicates, or omissions; and the underlying search query defines and constrains the scope shown. As a result, the analysis may be incomplete or inaccurate and may not reflect the full technology landscape.

Nothing on this page constitutes an exhaustive prior-art, novelty, freedom-to-operate, or validity search, nor does it constitute legal, financial, investment, or professional advice, and it should not be relied upon as such. Any patent, commercial, or strategic decision should be verified independently and reviewed with qualified patent, legal, and domain professionals. Patsnap makes no warranties, express or implied, as to the accuracy, completeness, or fitness for any particular purpose of the information presented.

Machine translation. Assignee and organisation names originally recorded in Chinese, Japanese or Korean have been rendered into English by an AI translation step so that the tables stay readable. These renderings are best-effort and may not match a company’s registered English name; the original name is what the underlying patent record carries, and it is what any Eureka query launched from this page uses.

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