Yeast Chassis Cofactor Engineering Patents: Leaders & Trends 2026
Yeast Chassis Cofactor Engineering Patents: Mapping Redox and Cofactor Claims in Engineered Yeast
34.7% concentration. The top 5 of 100 ranked assignees hold 102 of 294 records in scope — a third of the field sits with a handful of filers, the rest is a long tail. Annual records rose to a peak of 44 in 2018, then eased. Comparing 2021 (15 records) to 2024 (9 records) shows a 40% decline over that three-year span — the most recent complete-year comparison available; 2025 and 2026 figures are still filling in under normal publication lag and should not be read as a continued fall.
- 1DSM IP ASSETS BV30
- 2HUMAN GENOME SCI INC27
- 3ADISSEO FRANCE SAS17
- 4RADICI CHIM15
- 5LYGOS INC13
See the full yeast chassis cofactor engineering analysis in Eureka
- The complete ranking, not just the top five
- Every IPC branch with its share of the corpus
- The most-cited records, and where claim space is still thin
Common questions on this landscape
Who holds the most patents on yeast cofactor engineering?
The ranking covers 100 assignees across all 294 records in scope, and it is concentrated: the leading assignee holds 30 records, with the top 5 together accounting for 34.7% of all records. That still leaves close to two-thirds of the field spread across a long tail of companies and universities, many with only a handful of filings each. Anyone assessing this space should look at both the concentrated top and the long tail, since freedom-to-operate risk and white space typically sit in different places.
Is yeast cofactor engineering patent filing still growing?
Filing peaked at 44 records in 2018 and has cooled since; comparing 2021 (15 records) to 2024 (9 records) shows a 40% decline over that span, the most recent period that can be treated as complete. Filings from 2025 onward are still understated because publication typically lags the actual filing date by roughly 18 months. Treat any apparent recent drop with caution until later data cuts fill in.
What does US9297016B2 actually cover?
US9297016B2, assigned to GEVO, INC. and granted in 2016, covers a recombinant yeast host cell containing a dihydroxy-acid dehydratase polypeptide, plus host cells with increased activity of that polypeptide achieved through higher expression or modulation of Fe-S cluster biosynthesis. It also covers methods of using those host cells and methods for identifying polypeptides that increase flux through an Fe-S cluster biosynthesis pathway. Anyone engineering Fe-S cluster-dependent enzymes in a yeast chassis for a similar purpose should read the full claim set before designing a workaround.
Disclaimer. This analysis is based on Patsnap Eureka data drawn from a limited snapshot of global patent records and is provided for general information and reference only. Patent data carries inherent limitations — recent filings are under-counted because of publication lag, counts may be on a record or family basis, classification and applicant-name data may contain errors or duplicates, and the underlying search query defines the scope shown — so the analysis may be incomplete or inaccurate and may not reflect the full technology landscape.
Nothing here is an exhaustive prior-art, novelty, freedom-to-operate or validity search, nor does it constitute legal, financial or professional advice, and it should not be relied upon as such. Verify independently and review with qualified patent and legal professionals before acting on it.
Method: Filing trend and technology composition. Derived from a Patsnap search on Yeast Chassis Cofactor Engineering covering 2015–2026, data cut-off 2026-07-31. Counts reflect published records only and shift as new filings publish. Every share divides by all records in scope. Data: Patsnap Eureka. See the full landscape report.